Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. The SportsLine Projection Model simulates every FBS college football game 10,000 times. Clemson picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model. Iowa State odds from Caesars Sportsbook, while the over-under for total points scored is set at 45. The Tigers are two-point favorites in the latest Clemson vs. The Cyclones (7-5), who have won five of their last eight games, will make their school-record fifth consecutive bowl game appearance. Clemson would be just the third team to ever record double-digit wins for 11 straight years, joining Florida State (14 from 1987-2000) and Alabama (14 from 2008-2021).
The Tigers (9-3) have won seven of their last eight games after going just 2-2 in September.
19 Clemson Tigers will be eying their 11th consecutive 10-win season when they take on the Iowa State Cyclones in the 2021 Cheez-It Bowl on Wednesday at Camping World Stadium in Orlando, Fla.
